Evidence of Dementia Treatment using Vitamin D: A Systematic Review
Résumé
Dementia is a progressive cognitive decline that poses significant public health concerns, particularly among the ageing population. Recent evidence highlights vitamin D's neuroprotective roles, including its involvement in neurotransmission, antioxidative processes, and neuronal preservation. This systematic review examined ten studies from 2011 to 2020, including randomized controlled trials (RCTs), cross-sectional studies, and longitudinal studies, to evaluate vitamin D's efficacy in treating dementia. Findings demonstrated that vitamin D supplementation improves cognitive function, particularly in patients with mild cognitive impairment and dementia. High-dose supplementation exhibited enhanced effects on visuospatial memory and executive functions compared to low-dose supplementation in some studies. However, results varied due to differences in study populations, methodologies, and follow-up durations. Despite its limitations, including small sample sizes and short study periods, this review underscores the potential of vitamin D as a complementary intervention in dementia care. Further research is needed to establish optimal dosing and explore its long-term effects on cognitive health
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