Sero-Prevalence of Helicobacter pylori Infection among Pregnant Women Attending Antenatal Clinic in Garissa County, Kenya

  • Hassan Mohamed Kenyatta University
  • Harun Kimani Kenyatta University
  • Ephantus Kabiru Kenyatta University
Keywords: Sero-Prevalence, H. pylori, Pregnant Women, Antenatal Clinic
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The public health impact of H. pylori (HP) infection is gradually becoming evident. The bacterium is now being implicated as an etiologic agent in various gastric diseases. In developing countries, HP infection is markedly more prevalent at younger ages than in developed countries. According to the World Gastroenterology Organization, the prevalence of H. pylori in Kenya was 48% in ages between 2-4, 80% at the age of 6, and 95% in the adult population. The main objective of the study was to determine the prevalence of Pylori infection among pregnant patients attending the antenatal clinic in Garissa County, Kenya. This study utilized a cross-sectional study design to determine the prevalence of H. pylori infection. Probability proportion to the size and a simple random technique was used to collect the data. Blood samples drawn from study participants were tested according to the standard H. pylori tests and as per the Kit manufacturers’ instructions and procedure. Information from the laboratory analysis and questionnaires were then recorded in the questionnaire. Informed consent was obtained from the study participants before the study data collection tools were administered. Data Collected was entered into Excel and then exported to SPSS version 20. Frequencies and percentages were used to describe data, while Chi-square and binary logistic regression analysis were used to establish the association between the independent and dependent variables. Results show that the seroprevalence of H. pylori among sample pregnant women was 45%. Inferential analysis shows that respondents levels of education (χ2 = 10.07, df = 1, p = 0.002), parity (χ2 = 15.776, df = 3, p = 0.001) and type of toilet (χ2 (10.415(3), p = 0.015) was associated with the prevalence of H. pylori at bivariate level. Logistic regression analysis establishes that having a higher level of education (A.O.R = 2.483, p = 0.023, living in urban areas (A.O.R = 0.274, p = 0.014), being in casual employment A.O.R = 0.208 p = 0.024), having more than four children (A.O.R = 7.971, p = 0.006) and sharing of beds (A.O.R = 0.034, p = 0.0001) were predictors of H. pylori infection. This study concludes that about half of the study participants had H. pylori infection and socio-demographic and environmental conditions contribute to the prevalence. There is a need to sensitize pregnant women on the cause and prevention of H. pylori. Also, maintaining proper environmental and sanitation hygiene will aid in reducing transmission


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Abdella, B., Ibrahim, M., Tadesse, I., Hassen, K., & Tesfa, M. (2020). Association between Helicobacter pylori infection and occurrence of anemia among pregnant women attending antenatal care in Kulito health center, Halabi zone, south Ethiopia, 2018. Anemia, 2020.

Ahmed, N. F. M. (2016). The prevalence rate of Giardia lamblia/Helicobacter pylori co-infection in Khartoum state-Sudan. Sudan University of Science and Technology

Alvarado-Esquivel, C. (2013). Sero-epidemiology of Helicobacter Pylori Infection in Pregnant Women in Rural Durango, Mexico. International Journal of Biomedical Science: IJBS, 9(4), 224–229.

Baingana, R. K., Enyaru, J. K., & Davidsson, L. (2014). Helicobacter pylori infection in pregnant women in four districts of Uganda: role of geographic location, education and water sources. BMC Public Health, 14(1), 1-10.

Bardhan, P. K. (1997). Epidemiological features of Helicobacter pylori infection in developing countries. Clinical infectious diseases, 25(5), 973-978.

Bassily, S., Frenck, R. W., Mohareb, E. W., Wierzba, T., Savarino, S., Hall, E., ... & Clemens, J. (1999). Seroprevalence of Helicobacter pylori among Egyptian newborns and their mothers: a preliminary report. The American Journal of tropical medicine and hygiene, 61(1), 37-40.

Bunn, R. T., Darboe, M. K., Doherty, C. P., MacKay, W. G., Weaver, L. T., Campbell, D. I., & Thomas, J. E. (2003). Evaluation of 13C-urea breath test and fecal antigen immunoassay to detect Helicobacter pylori infection in Gambian infants. Journal of pediatric gastroenterology and nutrition, 44(5), 650-652.

Chey, W. D., Wong, B. C., & Practice Parameters Committee of the American College of Gastroenterology. (2007). American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Official Journal of the American College of Gastroenterology| ACG, 102(8), 1808-1825.

Development Initiatives. (2020). Progress of health and WASH in Kenya’s poorest ASAL counties: In-depth analysis of 10 arid and semi-arid land counties. Development Initiatives Poverty Research Ltd

Eslick, G. D., Yan, P., Xia, H. X., Murray, H., Spurrett, B., & Talley, N. J. (2002). Foetal intrauterine growth restrictions with Helicobacter pylori infection. Alimentary pharmacology & therapeutics, 16(9), 1677-1682.

Farag, T. H., Stoltzfus, R. J., Khalfan, S. S., & Tielsch, J. M. (2007). Unexpectedly low prevalence of Helicobacter pylori infection among pregnant women on Pemba Island, Zanzibar. Transactions of the Royal Society of Tropical Medicine and Hygiene, 101(9), 915-922.

Felkner, M., Suarez, L., Liszka, B., Brender, J. D., & Canfield, M. (2007). Neural tube defects, micronutrient deficiencies, and Helicobacter pylori: a new hypothesis. Birth Defects Research Part A: Clinical and Molecular Teratology, 79(8), 617-621.

Fisher, L. D. (1998). Self‐designing clinical trials. Statistics in medicine, 17(14), 1551-1562.

Goodman, K. J., & Cockburn, M. (2001). The role of epidemiology in understanding the health effects of Helicobacter pylori. Epidemiology, 266-271.

Karaer, A., Ozkan, O., Ozer, S., Bayir, B., Kilic, S., Babur, C., & Danişman, N. (2008). Gastrointestinal symptoms and Helicobacter pylori infection in early pregnancy. Gynecologic and obstetric investigation, 66(1), 44-46.

Kitagawa, M., Natori, M., Katoh, M., Sugimoto, K., Omi, H., Akiyama, Y., & Sago, H. (2001). Maternal transmission of Helicobacter pylori in the perinatal period. Journal of Obstetrics and Gynaecology Research, 27(4), 225-230.

Lwai-Lume, L., Ogutu, E. O., Amayo, E. O., & Kariuki, S. (2005). Drug susceptibility pattern of Helicobacter pylori in patients with dyspepsia at the Kenyatta National Hospital, Nairobi. East African Medical Journal, 82(12), 603-608.

Mitchell, H. M., Li, Y. Y., Hu, P. J., Liu, Q., Chen, M., Du, G. G., ... & Hazell, S. L. (1992). Epidemiology of Helicobacter pylori in southern China: identification of early childhood as the critical period for acquisition. Journal of infectious Diseases, 166(1), 149-153.

Mynepalli, S. K. C., Maureen, O., & Mumuni, A. (2014). Prevalence of Helicobacter pylori and hygiene practices among public secondary school students in Ikeja Local Government Area, Lagos, Nigeria. Health, 2014.

Naja, F. (2008). H. pylori Infection in Ontario: Prevalence, Risk Factors and Effect on the Bioavailability of Vitamins E and C (Doctoral dissertation).

Ogutu, E. O., Kang'ethe, S. K., Nyabola, L., & Nyong'o, A. (1998). Endoscopic findings and prevalence of Helicobacter pylori in Kenyan patients with dyspepsia. East African Medical Journal, 75(2), 85-89.

Torres, J., Leal-Herrera, Y., Perez-Perez, G., Gomez, A., Camorlinga-Ponce, M., Cedillo-Rivera, R., ... & Munoz, O. (1998). A community-based seroepidemiologic study of Helicobacter pylori infection in Mexico. The Journal of infectious diseases, 178(4), 1089-1094.

Wanyama, R., Kagawa, M. N., Opio, K. C., & Baingana, R. K. (2016). Effect of maternal Helicobacter Pylori infection on birth weight in an urban community in Uganda. BMC pregnancy and childbirth, 16(1), 1-8.

Weyermann, M., Rothenbacher, D., Gayer, L., Bode, G., Adler, G., Grab, D., ... & Brenner, H. (2005). Role of Helicobacter pylori infection in iron deficiency during pregnancy. American Journal of Obstetrics and gynaecology, 192(2), 548-553.

Yamaoka, Y. (2012). Pathogenesis of Helicobacter pylori-related gastroduodenal diseases from molecular epidemiological studies. Gastroenterology research and practice, 2012.

24 May, 2022
How to Cite
Mohamed, H., Kimani, H., & Kabiru, E. (2022). Sero-Prevalence of Helicobacter pylori Infection among Pregnant Women Attending Antenatal Clinic in Garissa County, Kenya. East African Journal of Health and Science, 5(1), 119-129.