Assessing Prevalence of Vaccination, Awareness, and Exposure to Risk Factors of Hepatitis B in Wa Municipality: A Descriptive Cross-Sectional Study

  • Florence Owusuaa Peprah Ghana Health Service
  • Alex Bapula Ghana Health Service
  • Kenneth Baga Sabogu I. M. Sechenov University
  • Moses Peprah Ghana Health Service
  • Ebenezer Akuoku Far Eastern Federal University
  • Jonathan Mawutor Gmanyami Global Health and Infectious Diseases Research Group
  • Richmond Bediako Nsiah Ghana Health Service
  • Samuel Malogae Badiekang Ghana Health Service
  • Isaac Morrison Kwame Nkrumah University of Science and Technology
  • Margaret Morrison National Health Insurance Authority
  • Dacosta Awuah Aboagye A1 Hospital
  • Khadijatu Adiss Yusif Ghana Health Service
  • Dominic Nyarko Ghana Health Service
  • Jerome Kaba Aperiba Ghana Health Service
  • Enoch Nyarko Food and Drugs Authority
  • Beverly Blankson Edinburgh Napier University
  • Isaac Ayirebi Saint Pauline Clinic
  • Peter Kipo Leta Ghana Health Service
Keywords: Hepatitis B, Vaccination Coverage, Risk Factors, Public Health Awareness, Wa Municipality, Ghana
Share Article:

Abstract

Background: Hepatitis B (HBV) in the Wa Municipality has increased over the past several years in Ghana, calling for urgent prevention and education interventions. This study evaluated awareness, vaccination coverage, and risk factors for HBV exposure in Wa Municipality, Ghana, to guide public health interventions. Methods: A cross-sectional study was conducted among 300 adults aged 18 years and above residing in Wa Municipality. A pre-tested questionnaire was used to collect information on demographic profile, knowledge about HBV, vaccination status, and history of exposure to major risk factors from January 1 to February 20, 2022. Statistical Package for Social Sciences (SPSS) version 22 was used to compute descriptive statistics and Pearson's correlation analysis. Results: The prevalence of full vaccination against HBV among respondents was 42%. The overall exposure to hepatitis B risk factors was 14.2%. Awareness of HBV was generally high, with about 81% exhibiting adequate awareness of risk factors, 92.6% of preventive measures and 80.6% of signs and symptoms of Hepatitis B. Statistically significant negative correlations were found between awareness of Hepatitis B exposure to risk factors (r = -0.282, p < 0.01), risk factors, (r = -0.251, p < 0.01) and preventive measures (r = -0.222, p < 0.01) and exposure to risk factors, and this increased awareness was linked with reduced risk exposure. Conclusion: Although Hepatitis B awareness is high in Wa Municipality, HBV vaccination is suboptimal. Targeted interventions must be implemented to optimise vaccination coverage and decrease HBV transmission in the Municipality. Future research must examine barriers to Hepatitis B vaccination, migration impact on HBV transmission, and the impact of interventions in progress.

Downloads

Download data is not yet available.

References

Abel, A. G., Shamarina, S., Nadzir, M., Noor, M., & Hafiz, R. A. (2025). Prevalence and Associated Risk Factors of Hepatitis B Virus Infection in Lafia Metropolis, Nasarawa State, Nigeria. African Journal of Infectious Diseases, 19(1), 45– 56. https://doi.org/https://doi.org/10.21010/Ajid v19i 1.6

Abesig, J., Chen, Y., Wang, H., Sompo, F. M., & Wu, I. X. Y. (2020). Prevalence of viral hepatitis B in Ghana between 2015 and 2019 : A systematic review and meta-analysis. PLoS ONE, 15(6), 1– 16. https://doi.org/10.1371/journal.pone.0234348

Adetola, M., Id, L., & Adeniyi, O. F. (2020). Prevalence of and risk factors for hepatitis B and C viral co-infections in HIV infected children in Lagos, Nigeria. PLOS ONE, 15(12), 1– 15. https://doi.org/10.1371/journal.pone.0243656

Al-busafi, S. A., Al-harthi, R., Al-naamani, K., Al-zuhaibi, H., & Priest, P. (2021). Risk Factors for Hepatitis B Virus Transmission in Oman. Oman Medical Journal, 36(4), 1–10. https://doi.org/10.5001/omj.2021.99

Ansa, G. A., Ofori, K. N. A., Houphouet, E. E., Amoabeng, A. A., Sifa, J. S., Amenuveve, C. K., & Odame, G. H. (2019). Hepatitis B vaccine uptake among healthcare workers in a referral hospital, Accra. Pan African Medical Journal, 33, 1– 10. https://doi.org/10.11604/pamj.2019.33.96.18042

Antuori, A., Not, A., Mesías-gazmuri, J., González, V., Montoro-fernandez, M., Folch, C., & Saludes, V. (2024). High Hepatitis B Prevalence and Vaccination Needs Among Transgender Women and Men Sex Workers in Barcelona , Spain. Open Forum Infectious Diseases, 11(8), 1–9. https://doi.org/10.1093/ofid/ofae410

Awili, H. O., Gitao, G. C., & Muchemi, G. M. (2020). Seroprevalence and Risk Factors for Hepatitis B Virus Infection in Adolescent Blood Donors within Selected Counties of Western Kenya. BioMed Research International, 2020, 1–6. https://doi.org/https://doi.org/10.1155/2020/8578172

Aynalem, A., Deribe, B., Ayalew, M., Mamuye, A., Israel, E., Mebratu, A., & Assefa, D. G. (2022). Practice towards Hepatitis B Virus Infection Prevention and Its Associated Factors among Undergraduate Students at Hawassa University College of Medicine and Health Sciences, Hawassa, Sidama, Ethiopia, 2021: Cross-Sectional Study. International Journal of Hepatology, 2022, 1–8. https://doi.org/https://doi.org/10.1155/2022/2673740

Bahadur, D., Id, S., Khadka, M., Khadka, M., & Subedi, P. (2020). Hepatitis B vaccination status and knowledge , attitude , and practice regarding Hepatitis B among preclinical medical students of a medical college in Nepal. PLOS ONE, 15(11), 1–11. https://doi.org/10.1371/journal.pone.0242658

Bayu, H., Elias, B., Abdisa, S., & Tune, A. (2020). Post exposure prophylaxis coverage , vertical transmission and associated factors among hepatitis B exposed newborns delivered at Arsi zone health institutions, 2019. PLOS ONE, 15(10), 1– 11. https://doi.org/https://doi.org/10.1371/journal. pone.0238987 Editor:

Efua, S. V., Armah, D., & Delali, W. (2023). Vaccine : X Hepatitis B virus vaccination post serological testing and antibody levels of vaccinated health care workers in Accra , Ghana. Vaccine: X, 14(2023), 100294. https://doi.org/https://doi.org/10.1016/j.jvacx.2023.100294

Faini, D. (2022). The Prevalence , Incidence , and Risk Factors for HIV Among Female Sex Workers — A Cohort Being Prepared for a Phase IIb HIV Vaccine Trial in Dar es Salaam , Tanzania. Journal of Acquired Immune Deficiency Syndromes, 91(5), 439–448.

Isunju, J. B., Tsebeni, S., Id, W., Ndejjo, R., Nuwematsiko, R., Bakkabulindi, P., Nalugya, A., Muleme, J., Kimara, K., Kibira, S. P. S., Nakiggala, J., Mugambe, R. K., Buregyeya, E., Id, T. S., & Wanyenze, R. K. (2022). Awareness of hepatitis B post-exposure prophylaxis among healthcare providers in Wakiso district, Central Uganda. PLOS ONE, 17(6), 1– 14. https://doi.org/https://doi.org/10.1371/journal. pone.0270181

Lang, F., Schoene, K., Goessler, F., Rose, D. M., & Kegel, P. (2022). Hepatitis A and hepatitis B infection risk among employees at schools for disabled pupils. Scientific Reports, 1–8. https://doi.org/10.1038/s41598-022-24579-7

Mutaru, A., Nanyim, J. K., & Adokiya, M. N. (2023). Knowledge and predictors of attitudes of hepatitis B virus infection prevention among adults in Tolon , Northern Ghana. Journal of Infection in Developing Countries, 17(8), 1152–1159. https://doi.org/10.3855/jidc.17127

Nguyen, T. T. L., Pham, T. T. H., So, S., Van Hoang, T. H., Nguyen, T. T. U., Ngo, T. B., Nguyen, M. P., Thai, Q. H., Nguyen, N. K., Le Ho, T. Q. A., Tran, Q. P., & Pham, M. K. (2021). Knowledge, attitudes and practices toward hepatitis b virus infection among students of medicine in Vietnam. International Journal of Environmental Research and Public Health, 18(13), 1–13. https://doi.org/10.3390/ijerph18137081

Ning, L., Niu, J., Bi, X., Yang, C., Liu, Z., Wu, Q., Ning, N., Liang, L., Liu, A., Hao, Y., Gao, L., & Liu, C. (2020). The impacts of knowledge, risk perception, emotion and information on citizens’ protective behaviors during the outbreak of COVID-19: a cross-sectional study in China. BMC Public Health, 20(1), 1–12. https://doi.org/10.1186/s12889-020-09892-y

Obeng, M. A., Okwan, D. K., Adankwah, E., Owusu, P. K., Gyamerah, S. A., Duah, K. B., & Paintsil, E. K. (2023). Seroconversion and Prevalence of Hepatitis B Surface Antigen among Vaccinated Health Care Workers in Ashanti Region, Ghana. Advances in Medicine, 2023, 1– 8. https://doi.org/https://onlinelibrary.wiley.com/doi/10.1155/2023/2487837

Odukoya, O. O., Odeyemi, K. A., Odubanjo, O. M., Isikekpei, B. C., Igwilo, U. U., Disu, Y. M., & Roberts, A. A. (2022). Hepatitis B and C Seroprevalence among Residents in Lagos State , Nigeria : A Population-Based Survey. Nigerian Postgraduate Medical Journal, 29, 75–81. https://doi.org/10.4103/npmj.npmj

Opare-Asamoah, K., Majeed, S. F., Owusu, A. O., Okyere, K., Owusu, E. A., Wondoh, P. M., Kunfah, S. M. P., Fosu, S. E., Yorke, J., Yakong, V. N., & Tabiri, S. (2021). The Prevalence and Risk Factors of Hepatitis B Virus Infection Among Dwellers in A Peri-Urban District of Ghana : A Cross- Sectional Study. Journal of Medical and Biomedical Sciences, 8(2021), 12–20.

Osei, E., Niyilapah, J., Kofi Amenuvegbe, G., & Liu, Y. (2019). Hepatitis B Knowledge, Testing, and Vaccination History among Undergraduate Public Health Students in Ghana. BioMed Research International, 2019. https://doi.org/10.1155/2019/7645106

Pereira, S. G., Moura, J., Carvalho, E., & Empadinhas, N. (2017). Microbiota of chronic diabetic wounds: ecology, impact, and potential for innovative treatment strategies. Frontiers in microbiology, 8, 296236.

Raina, D., Rawat, N., & Pandita, A. K. (2022). Prevalence of Hepatitis B and Hepatitis C in Patients undergoing hemodialysis at a teaching hospital in Uttarakhand. Journal of Family Medicine and Primary Care, 11(4), 1348–1353. https://doi.org/10.4103/jfmpc.jfmpc

Rasuli, R., Mohamad, M., & Yaacob, S. S. (2023). Comparing risk factors for hepatitis B infection between indigenous and non-indigenous population in Pahang based on a 5-year database. Medical Journal of Malaysia, 78(7), 883–889.

Rocha, L., Gabriela, L., Amaral, V., Winny, É., & Moura, A. (2023). Prevalence , Risk Factors and Vaccine Response against Hepatitis B in People Aged 50 Years or Older. MDPI Vaccine, 11(3), 597–612.

Savchuk, T., Grinvald, Y., & Ali, M. (2023). Antibodies to Hepatitis B core antigen prevalence study in Kazakhstan. Immunity, Inflammation and Disease, 11(3), 1–7. https://doi.org/https://doi.org/10.1002/iid3.793

Senoo-dogbey, V. E., Anto, F., Quansah, R., & Danso-, A. (2024). Completion of three-dose hepatitis B vaccination cycle and associated factors among health care workers in the Greater Accra Region of Ghana. PLOS ONE, 19(4), 1– 14. https://doi.org/10.1371/journal.pone.0298771

Spearman, C. W., Afihene, M., Ally, R., Apica, B., Awuku, Y., Cunha, L., Dusheiko, G., Gogela, N., & Kassianides, C. (2017). Hepatitis B in sub-Saharan Africa : strategies to achieve the 2030 elimination targets. The Lancet Gastroenterology & Hepatology, 2(12), 900– 909. https://doi.org/10.1016/S2468-1253(17)30295-9

Tassew, W. C., Ferede, Y. A., Zeleke, A. M., & Woldie, S. S. (2024). Practice on hepatitis B virus infection prevention and associated factors in Ethiopia : systematic review and meta-analysis. BMC Infectious Diseases, 24(1), 1–11.

Vyas, Y., Tsai, N. C., Katz, A. R., & Mph, T. P. (2024). Hepatitis B Prevalence and Risk Factors in Foreign-Born Asians and Pacific Islanders at a Federally Qualified Health Center in Hawai ‘ i , 2015-2020. Hawaii Journal Health Social Welfare, 83(2), 48–53.

Weldebrhan, D. (2023). Risk Factors for Hepatitis B Virus Infection in North Ethiopia : A Case – Control Study. Hepatic Medicine: Evidence and Research, 15, 79– 91. https://doi.org/https://doi.org/10.2147/HMER.S407069

Wondmagegn, M., & Wondimeneh, Y. (2022). Seroprevalence of Hepatitis B Virus , Hepatitis C Virus , Syphilis and Associated Factors Among Female Sex Workers in Gondar Town , Northwest Ethiopia. Infection and Drug Resistance, 15, 5915–5927. https://doi.org/https://doi.org/10.2147/IDR.S380952

Zhao, X., & Lv, M. (2021). Prevalence and factors associated with hepatitis B virus infection among household members : a cross-sectional study in Beijing. Human Vaccines & Immunotherapeutics, 17(6), 1818–1824. https://doi.org/10.1080/21645515.2020.1847951

Published
18 September, 2025
How to Cite
Peprah, F., Bapula, A., Sabogu, K., Peprah, M., Akuoku, E., Gmanyami, J., Nsiah, R., Badiekang, S., Morrison, I., Morrison, M., Aboagye, D., Yusif, K., Nyarko, D., Aperiba, J., Nyarko, E., Blankson, B., Ayirebi, I., & Leta, P. (2025). Assessing Prevalence of Vaccination, Awareness, and Exposure to Risk Factors of Hepatitis B in Wa Municipality: A Descriptive Cross-Sectional Study. East African Journal of Health and Science, 8(2), 378-391. https://doi.org/10.37284/eajhs.8.2.3671

Most read articles by the same author(s)